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The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. The product of methylation, 2-amino-6-methylthiopurine, is also substantially less active and less toxic than Thioguanine and its formation is likewise unaffected by the presence of allopurinol. Case reports have suggested that thiazide diuretics may increase the risk of allopurinol-induced hypersensitivity reactions, especially in patients with renal insufficiency. Allopurinol will not relieve a gout attack that has already started. After you have been taking allopurinol regularly for several months, the attacks may stop completely. You will need to discuss the benefits and risks of using Allopurinol while you are pregnant.

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