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Triamterene interferes with the fluorescent measurement of quinidine, resulting in erroneous values of the serum quinidine concentration. Hyperkalemia may complicate any of the following conditions: chronic renal failure, systemic acidosis, such as diabetic acidosis, acute dehydration, extensive tissue breakdown as in severe burns, adrenal insufficiency, or the administration of a potassium-sparing diuretic (eg, spironolactone, triamterene, amiloride) (see OVERDOSAGE). A case of cholestatic jaundice and centrolobular necrosis of the liver has been associated with triamterene (probably related to hypersensitivity to the drug). Triamterene is used to treat the following conditions: Ascites, Edema. Triamterene may cause a spurious elevation in serum lactate dehydrogenase concentrations.

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